Reaction: 15k-LXA4 is reduced to dhk-LXA4 by PTGR1
- in pathway: Synthesis of Lipoxins (LX)
Prostaglandin reductase 1 (PTGR1) aka LTB4DH, a 15-oxoprostaglandin 13-reductase (Yokomizo et al. 1996), metabolises 15-oxo lipoxin A4 aka 15-keto-LXA4 (15k-LXA4) to produce 13,14-dihydro-15-keto-Lipoxin A4 (dhk-LXA4). This reaction has been inferred from a reaction in pig (Clish et al. 2000).
Reaction - small molecule participants:
NADP+ [cytosol]
dhk-LXA4 [cytosol]
H+ [cytosol]
15k-LXA4 [cytosol]
NADPH [cytosol]
Reactome.org reaction link: R-HSA-2161844
======
Reaction input - small molecules:
hydron
15-oxolipoxin A4
NADPH(4-)
Reaction output - small molecules:
NADP(3-)
13,14-dihydro-15-oxolipoxin A4
Reactome.org link: R-HSA-2161844