Reaction: Arachidonic acid is epoxidated to 5,6-EET by CYP(4)
Several cytochrome P450s (CYPs) convert arachidonic acid to 5,6-epoxyeicosatrienoic acid (5,6-EET). The CYPs and their references are as follows: CYP1A1, CYP1A2, CYP1B1 (Choudhary et al. 2004); CYP2J2 (Wu et al. 1996).
Reaction - small molecule participants:
H2O [cytosol]
NADP+ [cytosol]
5,6-EET [cytosol]
H+ [cytosol]
O2 [cytosol]
AA [cytosol]
NADPH [cytosol]
Reactome.org reaction link: R-HSA-2161890
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Reaction input - small molecules:
hydron
dioxygen
arachidonate
NADPH(4-)
Reaction output - small molecules:
water
NADP(3-)
5,6-EET
Reactome.org link: R-HSA-2161890