Reaction: Arachidonic acid is epoxidated to 8,9/11,12/14,15-EET by CYP(5)
Several cytochrome P450s (CYPs) convert arachidonic acid to 8,9-, 11,12-, and 14,15-epoxyeicosatrienoic acids (8,9-, 11,12-, 14,15-EETs). The CYPs and their references are as follows: CYP1A1, CYP1A2, CYP1B1 (Choudhary et al. 2004); CYP2C8, CYP2C9 (Rifkind et al. 1995); CYP2C19 (Bylund et al. 1998, Rifkind et al. 1995); CYP2J2 (Wu et al. 1996).
Reaction - small molecule participants:
H2O [cytosol]
NADP+ [cytosol]
H+ [cytosol]
O2 [cytosol]
AA [cytosol]
NADPH [cytosol]
Reactome.org reaction link: R-HSA-2161899
======
Reaction input - small molecules:
hydron
dioxygen
arachidonate
NADPH(4-)
Reaction output - small molecules:
water
NADP(3-)
Reactome.org link: R-HSA-2161899