Reaction: 5S-HpETE is reduced to 5S-HETE by GPX1/2/4
- in pathway: Synthesis of 5-eicosatetraenoic acids
Glutathione peroxidase 1 (GPX1) (Bryant et al. 1982, Sutherland et al. 2001), 2 (GPX2) (Chu et al. 1993), and 4 (Bryant et al. 1982, Sutherland et al. 2001) reduce 5-hydroperoxyeicosatetraenoic acid (5-HpETE) to 5-hydroxyeicosatetraenoic acid (5-HETE) in the presence of glutathione (GSH). This reaction is inferred from the event in rabbit involving the protein GPX1 (Chiba et al. 1999).
Reaction - small molecule participants:
5S-HETE [cytosol]
H2O [cytosol]
GSSG [cytosol]
5S-HpETE [cytosol]
GSH [cytosol]
Reactome.org reaction link: R-HSA-2161946
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Reaction input - small molecules:
5(S)-HPETE
glutathionate(1-)
Reaction output - small molecules:
5(S)-HETE
water
glutathione disulfide(2-)
Reactome.org link: R-HSA-2161946