Reaction: Arachidonic acid is oxidised to 15R-HETE by Acetyl-PTGS2
- in pathway: Synthesis of 15-eicosatetraenoic acid derivatives
Aspirin acetylates the cyclooxygenase, prostaglandin G/H synthase 2 (PTGS2) aka COX2. The acetylated PTGS2 triggers the formation of 15R-hydroxyeicosatetraenoic acid (15R-HETE) from arachidonic acid (Claria & Serhan 1995).
Reaction - small molecule participants:
H2O [cytosol]
NADP+ [cytosol]
15R-HETE [cytosol]
H+ [cytosol]
O2 [cytosol]
AA [cytosol]
NADPH [cytosol]
Reactome.org reaction link: R-HSA-2161951
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Reaction input - small molecules:
hydron
dioxygen
arachidonate
NADPH(4-)
Reaction output - small molecules:
water
NADP(3-)
15(R)-HETE
Reactome.org link: R-HSA-2161951