Reaction: 12R-HpETE is reduced to 12R-HETE by GPX1/2/4
- in pathway: Synthesis of 12-eicosatetraenoic acid derivatives
Glutathione peroxidase 1 (GPX1) (Bryant et al. 1982, Sutherland et al. 2001), 2 (GPX2) (Chu et al. 1993), and 4 (Bryant et al. 1982, Sutherland et al. 2001) are involved in converting 12R-hydroperoxy-eicosatetraenoic acid (12R-HpETE) to 12R-hydro-eicosatetraenoic acid (12R-HETE).
Reaction - small molecule participants:
H2O [cytosol]
12R-HETE [cytosol]
GSSG [cytosol]
GSH [cytosol]
12R-HpETE [cytosol]
Reactome.org reaction link: R-HSA-2161959
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Reaction input - small molecules:
glutathionate(1-)
12(R)-HPETE
Reaction output - small molecules:
water
12(R)-HETE
glutathione disulfide(2-)
Reactome.org link: R-HSA-2161959