Reaction: 12S-HpETE is reduced to 12S-HETE by GPX1/2/4
- in pathway: Synthesis of 12-eicosatetraenoic acid derivatives
Glutathione peroxidase 1 (GPX1) (Bryant et al. 1982, Sutherland et al. 2001), 2 (GPX2) (Chu et al. 1993), and 4 (Bryant et al. 1982, Sutherland et al. 2001) are involved in converting 12S-hydroperoxy-eicosatetraenoic acid (12S-HpETE) to 12S-hydro-eicosatetraenoic acid (12S-HETE). GPXs are selenoenzymes that are responsible for reducing the cellular peroxide. Cellular GPXs compete with hepoxilins A3 (HXA3) synthase for 12S-HpETE as substrate either to produce 12S-HETE or to convert to HXA3, respectively.
Reaction - small molecule participants:
H2O [cytosol]
12S-HETE [cytosol]
GSSG [cytosol]
12S-HpETE [cytosol]
GSH [cytosol]
Reactome.org reaction link: R-HSA-2161999
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Reaction input - small molecules:
12(S)-HPETE
glutathionate(1-)
Reaction output - small molecules:
water
12(S)-HETE
glutathione disulfide(2-)
Reactome.org link: R-HSA-2161999