Reaction: AKT1 E17K mutant binds PIP2
- in pathway: Constitutive Signaling by AKT1 E17K in Cancer
Substitution of glutamic acid with lysine at position 17 of AKT1 results in constitutive plasma membrane localization of AKT1, independent of PI3K activity and PIP3 generation (Carpten et al. 2007). This constitutive plasma membrane targeting of AKT1 E17K mutant is due to an increased affinity for PIP2 (Landgraf et al. 2008).
Reaction - small molecule participants:
PI(4,5)P2 [plasma membrane]
Reactome.org reaction link: R-HSA-2219536
======
Reaction input - small molecules:
1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate(5-)
Reaction output - small molecules:
Reactome.org link: R-HSA-2219536