Reaction: SREBP1A,1C,2 binds SCAP:cholesterol:INSIG and is retained in the endoplasmic reticulum
- in pathway: Regulation of cholesterol biosynthesis by SREBP (SREBF)
SREBPs (SREBP1A/1C/2, SREBFs) bind SCAP in the endoplasmic reticulum membrane. Luminal loop 1 of SCAP binds cholesterol which prevents SCAP from interacting with Sec24 in the CopII coat complex and allows SCAP to interact with INSIG instead. These interactions retain SCAP:SREBP1A/1C/2 in the endoplasmic reticulum. The order of assembly of the SREBP1A/1C/2:SCAP:cholesterol:INSIG complex is unknown.
Reaction - small molecule participants:
CHOL [endoplasmic reticulum membrane]
Reactome.org reaction link: R-HSA-2317530
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Reaction input - small molecules:
cholesterol
Reaction output - small molecules:
Reactome.org link: R-HSA-2317530