Reaction: GSSeSG is reduced to GSSeH and GSH by GSR
- in pathway: Metabolism of ingested H2SeO4 and H2SeO3 into H2Se
Glutathione reductase (GSR) homodimer is involved in the reduction of selenodiglutathione (GSSeSG) into gluthathioselenol (GSSeH) and reduced glutathione (GSH). This reaction is inferred from the event in rat (Bjornstedt et al. 1992).
Reaction - small molecule participants:
GSH [cytosol]
NADP+ [cytosol]
GSSeH [cytosol]
H+ [cytosol]
NADPH [cytosol]
GSSeSG [cytosol]
Reactome.org reaction link: R-HSA-2408542
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Reaction input - small molecules:
hydron
NADPH(4-)
selenodiglutathione(2-)
Reaction output - small molecules:
glutathionate(1-)
NADP(3-)
glutathioselenol
Reactome.org link: R-HSA-2408542