Reaction: SeO3(2-) combines with GSH to form GSSeSG and GSSG
- in pathway: Metabolism of ingested H2SeO4 and H2SeO3 into H2Se
Selenite (SeO3(2-)) and reduced glutathione (GSH) spontaneously react to form selenodiglutathione (GSSeSG) and glutathione disulfide (GSSG). This has been proposed to be the major form of entry of selenium compounds into metabolism. This reaction is inferred from the event in rat (Bjornstedt et al. 1992).
Reaction - small molecule participants:
H2O [cytosol]
GSSeSG [cytosol]
GSSG [cytosol]
H+ [cytosol]
GSH [cytosol]
SeO3(2-) [cytosol]
Reactome.org reaction link: R-HSA-2408556
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Reaction input - small molecules:
hydron
glutathionate(1-)
selenite(2-)
Reaction output - small molecules:
water
selenodiglutathione(2-)
glutathione disulfide(2-)
Reactome.org link: R-HSA-2408556