Reaction: SOS mediated nucleotide exchange of RAS (SHC)
- in pathway: FCERI mediated MAPK activation
GRB2-bound SOS promotes the formation of active GTP-bound RAS. This activates the mitogen-activated protein kinase (MAPK) cascade, leading to cell growth and differentiation.
Reaction - small molecule participants:
GDP [cytosol]
GTP [cytosol]
GDP [cytosol]
GTP [cytosol]
Reactome.org reaction link: R-HSA-2424477
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Reaction input - small molecules:
GTP(4-)
GTP(4-)
Reaction output - small molecules:
GDP(3-)
GDP(3-)
Reactome.org link: R-HSA-2424477