Reaction: RDH8 reduces atRAL to atROL
- in pathway: The canonical retinoid cycle in rods (twilight vision)
The reversible, NADP(H)-dependent reduction of all-trans-retinal (atRAL) to all-trans-retinol (atROL) occurs in both rod and cone photoreceptor cells where multiple retinol dehydrogenases (RHDs) are located. RHDs belong to the short-chain dehydrogenase/reductase (SDR) superfamily. RDH8 (located in photoreceptor outer segments) is partially responsible, together with other RDHs, for mediating this reaction. The activity for human RDH8 is inferred from a bovine experiment (Rattner et al. 2000).
Reaction - small molecule participants:
atROL [cytosol]
NADP+ [cytosol]
H+ [cytosol]
atRAL [cytosol]
NADPH [cytosol]
Reactome.org reaction link: R-HSA-2464803
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Reaction input - small molecules:
hydron
all-trans-retinal
NADPH(4-)
Reaction output - small molecules:
all-trans-retinol
NADP(3-)
Reactome.org link: R-HSA-2464803