Reaction: TIRAP binds PIP2-rich regions in the plasma membrane
- in pathway: MyD88:MAL(TIRAP) cascade initiated on plasma membrane
Upon LPS stimulation, Mal(TIRAP) was shown to bind to PIP2-rich regions on the cell surface trough its phosphatidylinositol 4,5-bisphosphate-binding domain [Kagan JC and Medzithov R 2007]. TLR2 or 4 associates with Mal(TIRAP) on the cell surface, which in turn facilitates the binding of MyD88 to the activated TLR, leading to NF-kB and MAPK activation [Nunez Miguel R et al 2007, Nagpal K et al 2009].
Reaction - small molecule participants:
PI(4,5)P2 [plasma membrane]
Reactome.org reaction link: R-HSA-2559456
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Reaction input - small molecules:
1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate(5-)
Reaction output - small molecules:
Reactome.org link: R-HSA-2559456