Reaction: AKRs reduce RBP2:atRAL to RBP2:atROL
- in pathway: Retinoid metabolism and transport
RDH11 is the best-characterised enzyme that reduces all-trans-retinal (atRAL) to all-trans-retinol (atROL). In addition, several aldo-keto reductase (AKR) enzymes from subfamilies 1B and 1C also show all-trans-retinal (atRAL) reductase activity. AKR1B10 shows high reductase activity towards atRAL (Gallego et al. 2007, Ruiz et al. 2009) whereas AKR1C1, 1C3 and 1C4 all show much lower reductase activity towards arRAL (Ruiz et al. 2011).
Reaction - small molecule participants:
NADP+ [cytosol]
H+ [cytosol]
NADPH [cytosol]
Reactome.org reaction link: R-HSA-2855252
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Reaction input - small molecules:
hydron
NADPH(4-)
Reaction output - small molecules:
NADP(3-)
Reactome.org link: R-HSA-2855252