Reaction: COX10 transforms heme to heme O
- in pathway: Heme biosynthesis
Heme O and heme A are specifically synthesised for the heme-copper respiratory oxidases. Mitochondrial protoheme IX farnesyltransferase (COX10) mediates the transformation of protoheme IX (heme) and farnesyl diphosphate (FAPP) to heme O (Glerum & Tzagoloff 1994). COX10 is highly expressed in muscle, heart and brain (Murakami et al. 1997).
Reaction - small molecule participants:
heme O [mitochondrial matrix]
PPi [mitochondrial matrix]
heme [mitochondrial matrix]
FPP [mitochondrial matrix]
H2O [mitochondrial matrix]
Reactome.org reaction link: R-HSA-2995330
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Reaction input - small molecules:
ferroheme b
2-trans,6-trans-farnesyl diphosphate
water
Reaction output - small molecules:
heme o
diphosphate(3-)
Reactome.org link: R-HSA-2995330