Reaction: USP7 deubiquitinates TP53 and counteracts MDM2
- in pathway: Regulation of TP53 Degradation
USP7 (HAUSP) can deubiquitinate TP53, thereby prolonging TP53 half-life and enhancing TP53 activity (Li et al. 2002, Li et al. 2004, Sheng et al. 2006, Hu et al. 2006).
Reaction - small molecule participants:
H2O [nucleoplasm]
Reactome.org reaction link: R-HSA-3215310
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Reaction input - small molecules:
water
Reaction output - small molecules:
Reactome.org link: R-HSA-3215310