Reaction: KDM6B demethylates H3K27me3 on p16INK4A promoter
- in pathway: Oxidative Stress Induced Senescence
Histone demethylase KDM6B (JMJD3) demethylates H3K27Me3 marks i.e. removes methyl groups from lysine 28 of histone HIST1H3A on CDKN2A locus, thereby activating CDKN2A transcription. In human cells, H3K27Me3 marks are predominantly found around the first exon of p16INK4A, and KDM6B therefore activates p16INK4A transcription but not p14ARF transcription. In mouse cells, H3K27Me3 marks are found throughout the Cdkn2a locus and Kdm6b demethylase activity induces transcription of both p16Ink4a and p19Arf. KDM6B action promotes both the oncogene-induced and oxidative stress-induced senescence (Agger et al. 2009, Barradas et al. 2009).
Reaction - small molecule participants:
SUCCA [nucleoplasm]
2OG [nucleoplasm]
Reactome.org reaction link: R-HSA-3222593
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Reaction input - small molecules:
2-oxoglutarate(2-)
Reaction output - small molecules:
succinate(2-)
Reactome.org link: R-HSA-3222593