Reaction: GPX1 catalyzes 2 glutathione, reduced + H2O2 => glutathione, oxidized + 2 H2O
- in pathway: Detoxification of Reactive Oxygen Species
Glutathione peroxidase 1 (GPX1) located in the mitochondrial matrix (Bera et al. 2014) uses glutathione to reduce hydrogen peroxide (H2O2) to yield oxidized glutathione and water (Legault et al. 2000, Li et al. 2000, Faucher et al. 2003, Lu et al. 2012). As inferred from rat mitochondria, GPX1 is the major determinant of steady-state hydrogen peroxide levels (Antunes et al. 2002).
Reaction - small molecule participants:
GSSG [mitochondrial matrix]
H2O [mitochondrial matrix]
GSH [mitochondrial matrix]
H2O2 [mitochondrial matrix]
Reactome.org reaction link: R-HSA-3323013
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Reaction input - small molecules:
glutathione
hydrogen peroxide
Reaction output - small molecules:
glutathione disulfide(2-)
water
Reactome.org link: R-HSA-3323013