Reaction: GSR catalyzes glutathione (oxidized) + NADPH + H+ => 2 glutathione (reduced) + NADP+
- in pathway: Detoxification of Reactive Oxygen Species
Glutathione reductase (GSR) in the mitochondrial matrix regenerates reduced glutathione from oxidized glutathione and NADPH (Berkholz et al. 2008).
Reaction - small molecule participants:
NADP+ [mitochondrial matrix]
GSH [mitochondrial matrix]
H+ [mitochondrial matrix]
GSSG [mitochondrial matrix]
NADPH [mitochondrial matrix]
Reactome.org reaction link: R-HSA-3323079
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Reaction input - small molecules:
hydron
glutathione disulfide(2-)
NADPH
Reaction output - small molecules:
NADP(+)
glutathione
Reactome.org link: R-HSA-3323079