Reaction: GPX2 catalyzes 2 glutathione, reduced + H2O2 => glutathione, oxidized + 2 H2O
- in pathway: TP53 Regulates Metabolic Genes
GPX2 (located in the gastrointestinal tract, also called GSHPx-GI, GPX-GI, and GI-GPx), like glutathione peroxidase 1 (GPX1, ubiquitous), reduces one molecule of hydrogen peroxide (H2O2) with two molecules of glutathione to yield one molecule of oxidized glutathione (glutathione disulfide, GSSG) and two molecules of water (Chu et al. 1998).
Reaction - small molecule participants:
H2O [cytosol]
GSSG [cytosol]
GSH [cytosol]
H2O2 [cytosol]
H2O [cytosol]
GSSG [cytosol]
GSH [cytosol]
H2O2 [cytosol]
Reactome.org reaction link: R-HSA-3341277
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Reaction input - small molecules:
glutathionate(1-)
hydrogen peroxide
glutathionate(1-)
hydrogen peroxide
Reaction output - small molecules:
water
glutathione disulfide(2-)
water
glutathione disulfide(2-)
Reactome.org link: R-HSA-3341277