Reaction: GPX3 catalyzes 2 glutathione, reduced + H2O2 => glutathione, oxidized + 2 H2O
- in pathway: Detoxification of Reactive Oxygen Species
Glutathione peroxidase 3 (GPX3) in plasma reduces hydrogen peroxide (H2O2) with glutathione to yield oxidized glutathione and water (Maddipati and Marnett 1987, Takahashi et al. 1987, Chung et al. 2009, Ottaviano et al. 2009). Glutathione is synthesized in the liver and exported into the plasma.
Reaction - small molecule participants:
H2O [extracellular region]
GSSG [extracellular region]
H2O2 [extracellular region]
GSH [extracellular region]
Reactome.org reaction link: R-HSA-3341397
======
Reaction input - small molecules:
hydrogen peroxide
glutathione
Reaction output - small molecules:
water
glutathione disulfide(2-)
Reactome.org link: R-HSA-3341397