Reaction: PRDX6:GSTP1 catalyzes 2 glutathione, reduced + H2O2 => glutathione, oxidized + 2 H2O
- in pathway: Detoxification of Reactive Oxygen Species
Peroxiredoxin 6 (PRDX6) forms a heterodimer with GSTP1 (Pi Glutathione transferase) and catalyzes the reduction of hydrogen peroxide (H2O2) by glutathione to yield oxidized glutathione and water (Ralat et al. 2006, Ralat et al. 2008, Zhou et al. 2013).
Reaction - small molecule participants:
H2O [cytosol]
GSSG [cytosol]
GSH [cytosol]
H2O2 [cytosol]
Reactome.org reaction link: R-HSA-3343700
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Reaction input - small molecules:
glutathionate(1-)
hydrogen peroxide
Reaction output - small molecules:
water
glutathione disulfide(2-)
Reactome.org link: R-HSA-3343700