Reaction: SET1 complex trimethylates H3K4 at the MYC gene
The recruitment of SET1-type complexes at the MYC enhancer correlates with increased H3K4 trimethylation in vivo, a mark associated with active chromatin (Sierra et al, 2006). Studies in yeast have shown that H3K4 trimethylation depends on previous H2B ubiquitination by Rad6 and Bre1, which in turn are recruited to DNA by the Paf1 complex (reviewed in Shilatifard, 2006). In this context, the identification of Paf1 components as interactors with the C-terminal activation domain of beta-catenin is intriguing (Sierra et al, 2006)
Reaction - small molecule participants:
AdoHcy [nucleoplasm]
AdoMet [nucleoplasm]
Reactome.org reaction link: R-HSA-3364026
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Reaction input - small molecules:
S-adenosyl-L-methionine zwitterion
Reaction output - small molecules:
S-adenosyl-L-homocysteine zwitterion
Reactome.org link: R-HSA-3364026