Reaction: dc-Adenosyl methionine + Spermidine => Spermine + 5'-methylthioadenosine
- in pathway: Metabolism of polyamines
The protein encoded by this gene belongs to the spermidine/spermine synthases family. This gene encodes an ubiquitous enzyme of polyamine metabolism. Defects in SMS are the cause of Snyder-Robinson syndrome (SRS).
Reaction - small molecule participants:
SPN [cytosol]
MTAD [cytosol]
dc-AdoMet [cytosol]
SPM [cytosol]
Reactome.org reaction link: R-HSA-351210
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Reaction input - small molecules:
S-adenosylmethioninaminium
spermidine(3+)
Reaction output - small molecules:
spermine(4+)
5'-S-methyl-5'-thioadenosine
Reactome.org link: R-HSA-351210