Reaction: Putrescine + dc-Adenosyl methionine => Spermidine + 5'-methylthioadenosine
- in pathway: Metabolism of polyamines
Spermidine synthase is one of four enzymes in the polyamine-biosynthetic pathway and carries out the final step of spermidine biosynthesis. This enzyme catalyzes the conversion of putrescine to spermidine using decarboxylated S-adenosylmethionine as the cofactor.
Reaction - small molecule participants:
SPM [cytosol]
MTAD [cytosol]
dc-AdoMet [cytosol]
Putrescine [cytosol]
Reactome.org reaction link: R-HSA-351215
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Reaction input - small molecules:
S-adenosylmethioninaminium
1,4-butanediammonium
Reaction output - small molecules:
spermidine(3+)
5'-S-methyl-5'-thioadenosine
Reactome.org link: R-HSA-351215