Reaction: 2-oxoglutarate [mitochondrial matrix] + 2-oxoadipate [cytosol] <=> 2-oxoglutarate [cytosol] + 2-oxoadipate [mitochondrial matrix]
- in pathway: Lysine catabolism
SLC25A21, the mitochondrial 2-oxodicarboxylate carrier, mediates the exchange of 2-oxoadipate and 2-oxoglutarate across the inner mitochondrial membrane. While the exchange is reversible, under physiological conditions it proceeds in the direction of 2-oxoadipate import into the mitochondrial matrix and 2-oxoglutarate export (Fiermonte et al. 2001).
Reaction - small molecule participants:
2OG [cytosol]
aKADA [mitochondrial matrix]
2OG [mitochondrial matrix]
aKADA [cytosol]
Reactome.org reaction link: R-HSA-372480
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Reaction input - small molecules:
2-oxoglutarate(2-)
2-oxoadipic acid
Reaction output - small molecules:
2-oxoglutarate(2-)
2-oxoadipic acid
Reactome.org link: R-HSA-372480