Reaction: PCK2 phosphorylates OA to yield PEP
- in pathway: Gluconeogenesis
PCK2 (phosphoenolcarboxykinase), located in the mitochondrial matrix, catalyzes the physiologically irreversible reaction of oxaloacetate (OA) and GTP to form phosphoenolpyruvate (PEP), GDP, and CO2 (Modaressi et al. 1996, 1998).
Reaction - small molecule participants:
PEP [mitochondrial matrix]
GDP [mitochondrial matrix]
CO2 [mitochondrial matrix]
GTP [mitochondrial matrix]
OA [mitochondrial matrix]
Reactome.org reaction link: R-HSA-372819
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Reaction input - small molecules:
GTP(4-)
oxaloacetate(2-)
Reaction output - small molecules:
phosphonatoenolpyruvate
GDP(3-)
carbon dioxide
Reactome.org link: R-HSA-372819