Reaction: Translocation of Ezrin to plasma membrane
- in pathway: Netrin-1 signaling
Ezrin is a member of the ezrin/radixin/moesin (ERM) family that acts as a linker between the plasma membrane and the actin cytoskeleton. Ezrin exists in a dormant, monomeric form in which its FERM/NERMAD and C-ERMAD domains are associated, masking membrane and F-actin binding regions. On production of PIP2, ezrin binds it, is recruited to the plasma membrane, and undergoes conformational changes unmasking the two binding sites.
Reaction - small molecule participants:
PI(4,5)P2 [plasma membrane]
Reactome.org reaction link: R-HSA-374662
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Reaction input - small molecules:
1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate(5-)
Reaction output - small molecules:
Reactome.org link: R-HSA-374662