Reaction: EHMT1:EHMT2 methylates IL8 promoter
- in pathway: Senescence-Associated Secretory Phenotype (SASP)
EHMT1 (GLP) and EHMT2 (G9a) histone methyltransferases dimethylate histone H3 (HIST1H3A) on lysine residue 10, creating an H3K9Me2 mark on nucleosomes associated with the IL8 promoter (Takahashi et al. 2012).
Reaction - small molecule participants:
AdoHcy [nucleoplasm]
AdoMet [nucleoplasm]
Reactome.org reaction link: R-HSA-3788745
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Reaction input - small molecules:
S-adenosyl-L-methionine zwitterion
Reaction output - small molecules:
S-adenosyl-L-homocysteine zwitterion
Reactome.org link: R-HSA-3788745