Reaction: COMT transfers Met to DA to form 3MT
- in pathway: Enzymatic degradation of dopamine by COMT
Dopamine (DA) in the cytosol is methylated to 3-methoxytyramine (3MT) by catecholamine O-methyltransferase (COMT), which uses s-adenosylmethionine (AdoMet) as a methyl group donor (Männistö & Kaakkola 1991, Westerink & Spaan 1989).
Reaction - small molecule participants:
3MT [cytosol]
AdoHcy [cytosol]
AdoMet [cytosol]
DA [cytosol]
Reactome.org reaction link: R-HSA-379387
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Reaction input - small molecules:
S-adenosyl-L-methionine zwitterion
dopaminium(1+)
Reaction output - small molecules:
3-methoxytyramine
S-adenosyl-L-homocysteine zwitterion
Reactome.org link: R-HSA-379387