Reaction: CD28 bound PI3K phosphorylates PIP2 to PIP3
- in pathway: CD28 dependent PI3K/Akt signaling
PI3K enzyme bound to co-stimulatory protein CD28 catalyzes the phosphorylation of phosphatidylinositol 4,5-bisphosphate (PIP2) to generate phosphatidylinositol 3,4,5-trisphosphate (PIP3). This PIP3 acts as a membrane anchor for the downstream proteins like PDK1 and PKB.
Reaction - small molecule participants:
PI(3,4,5)P3 [plasma membrane]
ADP [cytosol]
ATP [cytosol]
PI(4,5)P2 [plasma membrane]
Reactome.org reaction link: R-HSA-389158
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Reaction input - small molecules:
ATP(4-)
1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate(5-)
Reaction output - small molecules:
1-phosphatidyl-1D-myo-inositol 3,4,5-trisphosphate(7-)
ADP(3-)
Reactome.org link: R-HSA-389158