Reaction: Activation of Rac1 by pVav1
- in pathway: CD28 dependent Vav1 pathway
Vav1, once activated by PIP3 binding and phosphorylation by Fyn, stimulates the GDP/GTP exchange activity of Rac. Vav1 is selective for Rac and catalyses exchange of bound GDP for GTP.
Reaction - small molecule participants:
GDP [cytosol]
GTP [cytosol]
Reactome.org reaction link: R-HSA-389348
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Reaction input - small molecules:
GTP(4-)
Reaction output - small molecules:
GDP(3-)
Reactome.org link: R-HSA-389348