Reaction: isocitrate + NADP+ => 2-oxoglutarate + CO2 + NADPH + H+
- in pathway: NADPH regeneration
Peroxisomal IDH1 (isocitrate dehydrogenase 1) homodimer catalyzes the reaction of isocitrate and NADP+ to form 2-oxoglutarate, CO2, and NADPH + H+. The same enzyme can also localize to the cytosol in at least some cell types (Geisbrecht and Gould 1999; Xu et al. 2004).
Reaction - small molecule participants:
H+ [peroxisomal matrix]
CO2 [peroxisomal matrix]
2OG [peroxisomal matrix]
NADPH [peroxisomal matrix]
ISCIT [peroxisomal matrix]
NADP+ [peroxisomal matrix]
Reactome.org reaction link: R-HSA-389550
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Reaction input - small molecules:
D-threo-isocitrate(3-)
NADP(+)
Reaction output - small molecules:
hydron
carbon dioxide
2-oxoglutarate(2-)
NADPH
Reactome.org link: R-HSA-389550