Reaction: Hydrolysis of ATP and release of tubulin folding intermediate from CCT/TriC
- in pathway: Formation of tubulin folding intermediates by CCT/TriC
Group II chaperonins enclose substrate proteins following substrate binding through the formation of a "built- in" lid over the central cavity. Upon ATP binding, lid formation is triggered by the transition state of ATP hydrolysis (Meyer, et al., 2003). In the case of CCT-mediated tubulin folding, one or more rounds of ATP hydrolysis are likely required before the association of non-exchangeable GTP with chaperonin-bound alpha tubulin.
Reaction - small molecule participants:
Pi [cytosol]
GTP [cytosol]
Reactome.org reaction link: R-HSA-389954
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Reaction input - small molecules:
GTP(4-)
Reaction output - small molecules:
hydrogenphosphate
Reactome.org link: R-HSA-389954