Reaction: 4,8,12-trimethyltridecanoyl-CoA + 2 O2 + 2 H2O + 2 NAD+ + 2 CoASH => 4,8-dimethylnonanoyl-CoA + 2 H2O2 + 2 NADH + 2 H+ + acetyl-CoA + propionyl-CoA
- in pathway: Beta-oxidation of pristanoyl-CoA
In two cycles of beta-oxidation mediated by the same enzyme activities responsible for the conversion of pristanoyl-CoA to 4,8,12-trimethyltridecanoyl-CoA, the latter molecule is converted to 4,8-dimethylnonanoyl-CoA. Two molecules each of O2, H2O, NAD+, and CoASH are consumed in the process and two molecules of H2O2 and NADH + H+ are generated, together with single molecules of acetyl-CoA and propionyl-CoA (Verhoeven et al. 1998).
Reaction - small molecule participants:
H+ [peroxisomal matrix]
4,8-dimethylnonanoyl-CoA [peroxisomal matrix]
propionyl CoA [peroxisomal matrix]
H2O2 [peroxisomal matrix]
Ac-CoA [peroxisomal matrix]
NADH [peroxisomal matrix]
O2 [peroxisomal matrix]
H2O [peroxisomal matrix]
CoA-SH [peroxisomal matrix]
4,8,12-trimethyltridecanoyl-CoA [peroxisomal matrix]
NAD+ [peroxisomal matrix]
Reactome.org reaction link: R-HSA-390276
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Reaction input - small molecules:
dioxygen
water
coenzyme A(4-)
4,8,12-trimethyltridecanoyl-CoA
NAD(1-)
Reaction output - small molecules:
hydron
4,8-dimethylnonanoyl-CoA
propionyl-CoA
hydrogen peroxide
acetyl-CoA(4-)
NADH(2-)
Reactome.org link: R-HSA-390276