Reaction: FAR1 reduces PalmCoA to HXOL
- in pathway: Wax biosynthesis
Peroxisomal fatty acyl-CoA reductase 1 (FAR1) catalyzes the reaction of palmitoyl-CoA (PalmCoA) and 2 NADPH + 2 H+ to form hexadecanol (HXOL), CoASH, and 2 NADP+. As judged from mRNA levels, FAR1 is widely expressed in the body (Cheng and Russell 2004).
Reaction - small molecule participants:
NADP+ [cytosol]
HXOL [cytosol]
CoA-SH [cytosol]
H+ [cytosol]
NADPH [cytosol]
PALM-CoA [cytosol]
Reactome.org reaction link: R-HSA-390425
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Reaction input - small molecules:
hydron
NADPH(4-)
palmitoyl-CoA(4-)
Reaction output - small molecules:
NADP(3-)
hexadecan-1-ol
coenzyme A(4-)
Reactome.org link: R-HSA-390425