Reaction: EP3 receptor can bind PGE2
- in pathway: Prostanoid ligand receptors
EP3 receptor mRNA are subject to alternative splicing at their 3'-ends and, to date, six expressed protein isoforms have been found in man (Yang J et al, 1994; Schmid A et al, 1995). These isoforms (not annotated here) differ in their G-protein coupling thereby contributing to the wide spectrum of EP3 actions: contraction of smooth muscle, enhancement of platelet aggregation, inhibition of autonomic neurotransmitter release, inhibition of gastric acid secretion, and inhibition of fat cell lipolysis.
Reaction - small molecule participants:
PGE2 [extracellular region]
Reactome.org reaction link: R-HSA-391933
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Reaction input - small molecules:
prostaglandin E2
Reaction output - small molecules:
Reactome.org link: R-HSA-391933