Reaction: EP2 and EP4 receptors can bind PGE2
- in pathway: Prostanoid ligand receptors
Once activated by PGE2, the EP2 (Regan JW et al, 1994) receptor:ligand complex can mediate downstream effects by coupling to the G protein alpha s subunit and activate adenylyl cyclase (Schwaner I et al, 1995). EP4 receptors (Bastien L et al, 1994) are present on smooth muscle cells and their effects are mediated via coupling to G protein alpha s subunit and subsequent stimulation of adenylate cyclase (Wilson RJ et al, 2004).
Reaction - small molecule participants:
PGE2 [extracellular region]
Reactome.org reaction link: R-HSA-391940
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Reaction input - small molecules:
prostaglandin E2
Reaction output - small molecules:
Reactome.org link: R-HSA-391940