Reaction: Soluble guanylate cyclase converts GTP to cGMP
- in pathway: Nitric oxide stimulates guanylate cyclase
Soluble guanylate cyclase (sGC) is a heterodimeric hemoprotein that selectively binds Nitric Oxide (NO). NO binding stimulates the synthesis of cGMP, which then binds to phosphodiesterases (PDE), ion-gated channels, and cGMP-dependent protein kinases (cGK) to regulate several physiological functions including vasodilation, platelet aggregation and neurotransmission.
Reaction - small molecule participants:
PPi [cytosol]
cGMP [cytosol]
GTP [cytosol]
PPi [cytosol]
cGMP [cytosol]
GTP [cytosol]
Reactome.org reaction link: R-HSA-392152
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Reaction input - small molecules:
GTP(4-)
GTP(4-)
Reaction output - small molecules:
diphosphate(3-)
3',5'-cyclic GMP
diphosphate(3-)
3',5'-cyclic GMP
Reactome.org link: R-HSA-392152