Reaction: p190RhoGEF exchanges GTP for GDP on RHOA, activating it
- in pathway: EPHB-mediated forward signaling
Receptor stimulation induces translocation of RHOA from the cytosol to the plasma membrane and subsequent activation of RHOA. Rho guanine nucleotide exchange factor 28 (p190RhoGEF, ARHGEF28) is a specific activator of RHOA that stimulates the exchange of GDP for GTP. In neuronal cells p190RhoGEF binds to and activates RHOA with its Dbl homology/pleckstrin homology domain (van Horck et al. 2001).
Reaction - small molecule participants:
GDP [cytosol]
GTP [cytosol]
Reactome.org reaction link: R-HSA-3928592
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Reaction input - small molecules:
GTP(4-)
Reaction output - small molecules:
GDP(3-)
Reactome.org link: R-HSA-3928592