Reaction: KALRN exchanges GTP for GDP on RAC1, activating it
- in pathway: EPHB-mediated forward signaling
The Dbl homology (DH) and pleckstrin homology (PH) domains of kalirin (KALRN) provides the GEF activity and is activated upon binding to EPHB. Activated KALRN with its GEF domains activates RAC1, and controls spine remodelling by modulating actin cytoskeletal rearrangements (Penzes & Jones 2008, Penzes et al. 2003).
Reaction - small molecule participants:
GDP [plasma membrane]
GTP [cytosol]
Reactome.org reaction link: R-HSA-3928612
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Reaction input - small molecules:
GTP(4-)
Reaction output - small molecules:
GDP
Reactome.org link: R-HSA-3928612