Reaction: Activation of Rho by LARG and PDZ-RhoGEF
- in pathway: Sema4D induced cell migration and growth-cone collapse
The RhoGEFs LARG and PDZ-RhoGEF complexed with Plexin-B1 stimulate the exchange of GDP for GTP on RhoA through their DH and PH domains.
Reaction - small molecule participants:
GDP [cytosol]
GTP [cytosol]
Reactome.org reaction link: R-HSA-416588
======
Reaction input - small molecules:
GTP(4-)
Reaction output - small molecules:
GDP(3-)
Reactome.org link: R-HSA-416588