Reaction: Recruitment and activation of N-WASP by Cdc42
- in pathway: DCC mediated attractive signaling
The adaptor protein Nck-1 binds to DCC and recruits Rac-1, Cdc42 and their effectors PAK-1 and N-WASP to the activated receptor. Both Cdc42 and Nck-1 are activators of N-WASP. Cdc42 in its active GTP bound form binds to the CRIB domain of N-WASP and this interaction along with PIP2 results in the activation of N-WASP. Nck-1 activate N-WASP via binding of its SH3 domain to the proline rich domain of N-WASP. Nck-1 also possess an SH2 domain that associates directly with activated tyrosine kinase receptors which can phosphorylate N-WASP.
Reaction - small molecule participants:
PI(4,5)P2 [plasma membrane]
Reactome.org reaction link: R-HSA-418874
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Reaction input - small molecules:
1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate(5-)
Reaction output - small molecules:
Reactome.org link: R-HSA-418874