Reaction: Ghrelin O-acyltransferase decanoylates Proghrelin
- in pathway: Synthesis, secretion, and deacylation of Ghrelin
Proghrelin is decanoylated by ghrelin O-acyltransferase (GOAT/MBOAT4), an enzyme present in the endoplasmic reticulum membrane which both transports the decanoic acid substrate and condenses it on the hydroxyl group of serine-3 of the mature protein. The most common acylated form of ghrelin is octanoyl ghrelin but decanoyl ghrelin is also detected in plasma. GOAT is able to use substrates up to tetradecanoic acid. Ghrelin is the only protein known to undergo such a modification.
Reaction - small molecule participants:
DECA [endoplasmic reticulum lumen]
Reactome.org reaction link: R-HSA-422017
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Reaction input - small molecules:
decanoic acid
Reaction output - small molecules:
Reactome.org link: R-HSA-422017