Reaction: Ghrelin O-acyltransferase octanoylates Proghrelin
- in pathway: Synthesis, secretion, and deacylation of Ghrelin
Proghrelin is octanoylated by ghrelin O-acyltransferase (GOAT/MBOAT4), an enzyme present in the endoplasmic reticulum membrane which both transports the octanoic acid substrate and condenses it on the hydroxyl group of serine-3 of the mature protein. The most common acylated form of ghrelin is octanoyl ghrelin but decanoyl ghrelin is also detected. Ghrelin is the only protein known to undergo such a modification.
Reaction - small molecule participants:
octanoic acid [endoplasmic reticulum lumen]
Reactome.org reaction link: R-HSA-422104
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Reaction input - small molecules:
octanoic acid
Reaction output - small molecules:
Reactome.org link: R-HSA-422104