Reaction: TTF1:rRNA promoter:ERCC6:EHMT2 complex dimethylates histone H3 at lysine-9.
As inferred from mouse, EHMT2 (histone methyltransferase G9a) dimethylates histone H3 at lysine-9 (H3K9me2) in the transcribed region of the rRNA gene. Dimethylation of histone H3 in the transcribed region causes increased rRNA expression, which contrasts with the repressive effect of H3K9me2 in other regions of the genome. The histone binding activity and ATPase activity of CHD4 in the NuRD complex are also needed for activation.
Reaction - small molecule participants:
AdoHcy [nucleoplasm]
AdoMet [nucleoplasm]
Reactome.org reaction link: R-HSA-427336
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Reaction input - small molecules:
S-adenosyl-L-methionine zwitterion
Reaction output - small molecules:
S-adenosyl-L-homocysteine zwitterion
Reactome.org link: R-HSA-427336