Reaction: 3-ketosphinganine + NADPH + H+ => sphinganine + NADP+
- in pathway: Sphingolipid de novo biosynthesis
KDSR (3-ketodihydrosphingosine reductase) enzyme associated with the cytosolic face of the endoplasmic reticulum membrane catalyzes the reduction of 3-ketosphinganine by NADPH to form sphinganine (dihydrosphingosine) (Kihara and Igarashi 2004).
Reaction - small molecule participants:
NADP+ [cytosol]
SPA [endoplasmic reticulum membrane]
H+ [cytosol]
NADPH [cytosol]
3-ketosphinganine [endoplasmic reticulum membrane]
Reactome.org reaction link: R-HSA-428123
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Reaction input - small molecules:
hydron
NADPH(4-)
3-dehydrosphinganine
Reaction output - small molecules:
NADP(3-)
sphinganine
Reactome.org link: R-HSA-428123