Reaction: ceramide + H2O => stearate + sphingosine [Golgi]
- in pathway: Sphingolipid metabolism
ACER2 (alkaline ceramidase 2), associated with the membrane of the Golgi apparatus, catalyzes the hydrolysis of ceramide to yield a free fatty acid (annotated here as stearate) and sphingosine. ACER2 mRNA is widely expressed in the body, although only at low levels except in placenta (Xu et al. 2006).
Reaction - small molecule participants:
SPG [Golgi membrane]
STEA [Golgi membrane]
H2O [cytosol]
CERA [Golgi membrane]
Reactome.org reaction link: R-HSA-428205
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Reaction input - small molecules:
water
N-acylsphingoid
Reaction output - small molecules:
sphingoid base(1+)
magnesium distearate
Reactome.org link: R-HSA-428205