Reaction: ceramide + H2O <=> stearate + sphingosine [endoplasmic reticulum]
- in pathway: Sphingolipid metabolism
ACER1 (alkaline ceramidase 1), associated with the endoplasmic reticulum membrane, catalyzes the reversible hydrolysis of ceramide to yield a free fatty acid (annotated here as stearate) and sphingosine (Sun et al. 2008).
Reaction - small molecule participants:
SPG [endoplasmic reticulum membrane]
STEA [early endosome]
H2O [cytosol]
CERA [endoplasmic reticulum membrane]
Reactome.org reaction link: R-HSA-428231
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Reaction input - small molecules:
water
N-acylsphingoid
Reaction output - small molecules:
sphingoid base(1+)
magnesium distearate
Reactome.org link: R-HSA-428231